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Therefore, the above-listed mutations, as a single event, appear to be insufficient for melanomagenesis, but bear partially transformed melanocytes which may have an increased susceptibility to additional pathogenic mutation(s) ( in situ ) as well as papulonodular tumorigenic dermal proliferations (melanocytomas), and both categories are subclassified into low-grade and high-grade ( BRAF or NRAS (29)
Ahren B, Hirsch IB, Pieber TR, Mathieu C, Gomez-Peralta F, Hansen TK, et al
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Importantly, clinical studies typically have indiscriminately tested interventions and have rarely utilised biomarkers or clinical symptoms to identify treatment responders, so the clinical indications are in some cases based on the authors opinion regarding the rationalisation of different management options
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