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In contrast, its use in specific clinical contextssuch as circadian rhythm sleep disorders, neurodegenerative diseases, or metabolic dysregulationis addressed as an adjunctive therapeutic approach, where evidence remains heterogeneous and often limited to small-scale or short-term studies

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For example, CTLA-4, an inhibitory receptor expressed primarily by T cells, dampens T-cell activity and is upregulated upon T-cell activation 84,85

Downregulation of LAT1 ( SLC7A5 ) suppresses methionine input, thus reducing the level of cellular SAM, resulting in methylation depletion of some histones and inhibition of tumor growth