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Adding persistent foamy urine to other symptomslike swelling in the hands, ankles, or around the eyesshould raise concern

Meta-analyses using data from randomized, controlled CV outcomes trials showed that GLP-1 RAs were associated with a significant reduction in the risk of three-component major adverse CV events (CV death, non-fatal myocardial infarction and non-fatal stroke), and a significant reduction in the risk of fatal or non-fatal stroke, versus placebo in addition to standard-of-care (SoC) treatment [13, 14]

By late 2025, the KFF Health Tracking Poll found that one in eight American adults had taken a GLP-1 drug, a figure projected to rise to one in four by 2030

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