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Supplementary material The Supplementary Material for this article can be found online at: Glossary -SMA -smooth muscle actin AKI acute kidney injury APS astragalus polysaccharides AS-IV Astragaloside IV BUN blood urea nitrogen cGAS cyclic GMP-AMP synthase CKD chronic kidney diseases CPs combined pellet system ECM extracellular matrix EGCG Epigallocatechin-3-O-gallate NP nanoparticle EMT epithelial-mesenchymal transition EZH2 enhancer of zeste homolog-2 H3K27me3 histone H3 lysine 27 trimethylation HO-1 Heme oxygenase-1 IL-1 interleukin-1 miRs microRNAs MMP7 matrix metalloproteinase7 PAA Poricoic acid A PAI plasminogen activator inhibitor PDGF platelet-derived growth factor RAAS renin-angiotensin-aldosterone system RTECs renal tubular epithelial cells Sal Salidroside SalB Salvianolic acid B SNEDDS self-nanoemulsifying drug delivery system SOD superoxide dismutase STAT6 signal transducer and activator of transcription 6 STING stimulator of interferon genes TAS total astragalus saponin TCM Traditional Chinese Medicine TRA total rhubarb anthraquinone TSP-1 thrombospondin-1 UUO unilateral ureteral obstruction References 1 AhmedyO.El-TanboulyD.Al-MokaddemA.El-SaidY

While each component stands fully capable of supporting normal cellular function on its own, our research strongly suggests that the proper ratio found in Profaya yields a greater result than the sum of its parts