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IGF-1-1 and IGF-2 are primarily produced in the liver and to a lesser extent locally in target tissues where they exert autocrine and paracrine actions

Research Applications Synergistic Pathway Studies: Investigate combined angiogenesis and cellular migration mechanisms in experimental models

Published microarray analyses have reported effects on genes involved in anti-inflammatory responses, antioxidant defense systems, stem cell markers, and DNA repair pathways

It is not yet known whether PCBPs mediate ferritin iron loading in the intestinal enterocyte, but if enterocytes do rely on PCBPs, they may also serve as a limiting component for body iron accrual by directing and loading the metal to ferritin