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Figure 4 Molecular alterations in a target protein can also result in acquired drug resistance, such as crizotinib resistance in lung adenocarcinoma, which occurs due to a secondary mutation (G2032R) in the reactive oxygen species (ROS) proto-oncogene 1 (ROS1) kinase domain ( MET ) ( EGFR -mutant cancer cell lines revealed that gefitinib resistance was associated with an oncogenic mutation in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)

Membrane redox state and apoptosis: death by peroxide