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Using highly multiplexed antibody staining with imaging mass cytometry, we identified the emergence of stress-associated microglia (SAM) using a spatial proteomics method in the brains of 2HIT mice, which highly express TGF, APOE, MHC-class II, IL-6, and TREM2 proteins

When used as part of a supervised wellness program, GLP-1 therapies work by interacting with receptors in the brain, pancreas, and digestive system

Exenatide and lixisenatide are exendin based GLP-1 receptor agonists

Mounjaro works by activating both GLP-1 and GIP receptors, increasing insulin secretion, decreasing glucose production by the liver, reducing hunger and cravings, and promoting satiety leading to less food intake and weight loss