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### Discard the Vial If: - It has been more than 30 days since reconstitution - You see cloudiness, particles, or color changes - The vial was left at room temperature for more than a few hours - You suspect contamination (e.g., the stopper was touched without cleaning) When in doubt, discard and start fresh

Opioid therapy remains important in oncology, but guidelines emphasize careful titration to balance effective pain relief with risks such as sedation, constipation, and respiratory depression

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To view a copy of this licence, visit About this article Cite this article Joseph, R., Apollon, W., Jean-Baptiste, M.C