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RNA based immune signatures may Predict Responses to PD-1 Inhibition and Azacitidine Treatment in Acute Myeloid Leukemia (AML): A subset analysis of a Phase 2 Study

The induction of MPT triggers release of intermembrane proteins such as apoptosis inducing factor (AIF) and endonuclease G into the cytosol and their translocation to the nucleus, causing nuclear DNA fragmentation and activation of regulated necrosis