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Data processing and statistical analysis Peak areas were obtained from Tracefinder with a target compound list of compounds of interests at a window of five parts per million accuracy (see Supplementary Tables S4S6)
Fragmentation voltages/collision energy were optimized at 120 V/16 eV for carnitine, 90 V/14 eV for IS, respectively, for the best response of the transitions
Mobile phase A was 90% ACN + 5 mM AmFm +0.5% formic acid
In both experimental models and human diabetic subjects, there is an initial metabolic phase that is responsive to metabolic corrections [90, 91]
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