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Funding The National Key Research and Development Program (2018YFE0196600), the China Postdoctoral Science Foundation (2020M670131), and the Beijing Postdoctoral Research Foundation (2020-ZZ-045)
Injection Site Reactions Because tirzepatide is administered subcutaneously (under the skin), injection site reactions are relatively common: Redness, itching, or swelling at the injection site Minor bruising or tenderness Warmth or mild discomfort These reactions are usually mild and self-limiting
Normal C57Bl/6J mice had baseline three-chamber testing performed seven days before pump placement, the open field anxiety test was performed six days prior to pump placement, marble burying was performed five days prior to pump placement, and weight was measured immediately following pump placement
Arrhythmia-specific Test tube and animal experiments indicate that the long-chain omega-3 PUFAs help stabilize ischemic heart muscle cells and reduce susceptibility to arrhythmias
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