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It predominantly affects women

Patients with wasting diseases (most famously HIV/AIDS) Patients with lung cancer and other pulmonary diseases Patients with major injuries, sepsis, and trauma Patients with gut diseases like Inflammatory Bowel Disease (Crohns Disease and ulcerative colitis) Patients with Chronic Fatigue Syndrome Overtrained athletes People with alcoholism or fatty liver disease People with diabetes and lower glucose tolerance In many of these cases, raising glutathione levels has shown some therapeutic benefits

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It is often paired with a GHRH analog such as CJC-1295 in research settings to combine the two complementary GH-release pathways