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What they found: Plasma NAD+ increased by 60 % in the NR arm Mild reduction of systolic blood pressure by 6 mmHg Improvement in arterial stiffness (markers of endothelial function) No effect on glycemia in the healthy population Excellent safety profile , no serious adverse events Why it matters: The study validated the oral bioavailability of NR and the ability to long-term increase the NAD+ pool in humans

The FDA reaffirmed the decision on December 19, 2024

Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, et al

Release of immune effectors and/or inflammatory polarization of microglia is a logical suspicion, but there may be a more intriguing mechanism at play as suggested by an interesting series of papers by Lisak et al