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In a double-blind, randomized, controlled clinical trial, LAC was not inferior to amisulpride in relieving symptoms of dysthymic patients, showing an excellent profile of safety and tolerability [61]

Prior to the initiation of valproic acid therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

Unmixed powder keeps best frozen or refrigerated and away from light

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