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Conventional delivery of antioxidants faces several challenges, including poor bioavailability, low stability, rapid clearance, short half-life, poor targeting, non-specific distribution, gastrointestinal degradation, low penetration of biological barriers, cytotoxicity, and pro-oxidant effects at high doses [31]

At present, the highly recognized pathogenic mechanism is a multiple hit hypothesis, which considers the combined effects of multiple insults on genetically susceptible subjects to induce NAFLD and provides a reasonable explanation for the development of NAFLD (47)

130 Even when these tests are used, significant overlap of values is noted in persons with cirrhosis and less severe degrees of liver scarring, limiting their utility

Thermal, light, and storage stability of free and encapsulated folic acid was much higher in orange juice, which is rich in ascorbic acid, in contrast to apple juice, likely due to the above-mentioned protective effect of ascorbic acid 546