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Accordingly, Rfx6 acts upstream of late acting transcription factors Aristaless-related homeobox (Arx), Paired box gene (Pax) 6 and Insulin gene enhancer protein (Isl) 1, regulating enterohormone gene transcription and as such, controlling terminal differentiation of enteroendocrine cell subtypes (46)

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On the Arizona Trail, I watched a hiking partner's condition deteriorate over a single hot afternoon because she was drinking plenty of water but not replacing what she was sweating out

In the Phase 3 TRIUMPH-1 obesity trial, patients on the highest dose lost an average of 70.3 pounds, or 28.3% of body weight, over 80 weeks