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We are also recommending that if patients are starting these drugs or increasing the dose of these drugs, they should do so slowly to reduce the risk of dropping their blood sugar and causing an osmotic shift. Bradley Katz, MD, PhD We as well as other concerned physicians are also asking FDA to mandate a post-marketing survey of these drugs to find the true incidence of eye complications associated with them

78%) [Figure 3.6]

[5] [11] Some sleep difficulties reported during trials may therefore reflect the underlying condition rather than a direct drug effect

Brain-derived neurotrophic factor (BDNF) is involved in the regulation of energy homeostasis, acting as a satiety signal downstream of leptinmelanocortin signaling