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Regarding AR, 5 studies from Brazil, Mexico, and Ecuador evaluated the association between CAG repeat length in the AR gene and the risk of PCa, three of which reported an increased risk with 21 CAGs (49, 66) y 20 CAGs and lower PCa aggressiveness was reported (74), and in Mexico, its ability to differentiate PCa from BPH was observed (112)

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In preclinical models, these molecules improve bone mass [107], trabecular and cortical architecture [109,110,111], bone strength [112], and collagen content [111], but do not affect bone mineral density [113,114,115]