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Switching patterns following formulary change Switching from AOM tirzepatide remained rare prior to May 2025, averaging 0.6% of patients who switched to a different GLP-1 in the following month

The GLP-1 receptor agonists work by mimicking the GLP-1 hormone in the gut, and the dual agonists work by mimicking both the GLP-1 and GIP hormones, which regulate blood glucose and appetite

Rybelsus mimics incretin hormones , leading to increased insulin release, reduced glucagon secretion, and delayed gastric emptying, potentially causing weight loss

But if you notice swelling of your face or have strong pain in your belly, you should see your healthcare provider right away