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Semaglutide constipation treatment options: when to contact a healthcare provider The interventions above work well for many people, but you may need further treatment if you have any of the following symptoms : Severe stomach pain Abdominal swelling Rectal bleeding Inability to pass gas Vomiting These symptoms could indicate a more serious GI issue that requires medical treatment, so seek medical attention if you experience them, or if you have other side effects youd like to discuss