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Sano et al., 2016

The fastest weight loss typically occurs between weeks 8 and 20 of treatment, precisely when the dose is climbing from 5mg to 10mg or higher

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For trained users actively trying to preserve or build muscle on GLP-1, the target should be 1.6 to 2.3 grams per kilogram of fat-free mass , significantly higher than the commonly cited 1.2 to 1.6 g/kg total bodyweight standard