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It adds that people over 65, those with kidney disease, and those taking multiple gastrointestinal medications need a careful medication review before starting any pain reliever

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In contrast, a subsequent larger randomized controlled trial evaluating global non-motor outcomes including cognition, mood, and quality of life, did not find statistically significant overall improvements, suggesting that the benefits of GLP-1 agonists may be more domain-specific than generalizable across all non-motor symptoms [32]