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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

Thats why providers sometimes add tests like amylase and lipase or order scans if abdominal pain pops up

Figure 5: Changes in tissue weight in lean mice and obese mice across the three different experimental treatment groups

(79(7)):607-610 doi:10.1038/s41430-025-01583-4