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Orforglipron: A Breakthrough in Oral GLP-1 Small-Molecule Drug Development On April 1, 2026, Eli Lilly and Company announced that its oral small-molecule GLP-1 receptor agonist Orforglipron had received approval from the U.S

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FDA prescribing information for medications like Wegovy (semaglutide) and Mounjaro (tirzepatide) includes warnings that acute gallbladder disease has been reported in clinical trials