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Other notable adverse effects include: Injection site reactions : Mild erythema, itching, or swelling at the subcutaneous injection site Hypoglycaemia : Particularly when tirzepatide is used in combination with insulin or sulphonylureas

Safety Considerations for Fertility Planning on Semaglutide Semaglutide is not directly teratogenic, but pregnant patients should discontinue the medication because safety in pregnancy has not been established in humans

Patients should be counseled that these symptoms are expected and generally not indicative of serious pathology, though persistent or severe symptoms warrant medical evaluation

2021 Nov 10;12:786732