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In additional experiments, treatment of DIO rats with GEP12 at 10 nmol/kg/day resulted in significant reductions in food intake and body weight (food intake: mean difference 41.3 kcal/day, 95% CI 62.8 to 19.9 kcal/day, p = 0.0019

This basic work set up the biochemical basis for IGF1 LR3s enhanced uptake and potency