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In particular, glutathione and MT conjugates of several metals are formed in the olfactory epithelium and are transported by pinocytosis by the olfactory axons to the brain, thus evading the blood-brain barrier (BBB) [156]

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Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years