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137 In GC, the novel natural product inhibitor of STAT3 termed XYA-2 might exert its anticancer activity by synergistically inhibiting the expression of MYC and ZIP10, two downstream genes of STAT3 in vitro and in vivo
Understanding what each peptide does, and why they work better together, is essential for evaluating whether this protocol is appropriate
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In addition, butyrate treatment increased acetylation in the promoters of TNF- and IL-6, but it blocked the binding of RNA polymerase II to these genes, resulting in suppressed transcription initiation
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