risks semaglutide cardiovascular outcomes align more closely with attained dose than achieved weight loss The multifaceted effects of semaglutide:

Gastrointestinal bleeding: Upper gastrointestinal bleeding can result from various conditions such as ulcers, gastritis, esophagitis, Mallory-Weiss syndrome, and stomach cancer, which might lead to black stools

Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism

Beyond the absolute contraindications, several situations call for heightened caution in the class framing and are firmly a clinicians domain: a history of pancreatitis or symptomatic gallstones, significant gastrointestinal motility disorders (such as gastroparesis, which slowed gastric emptying can worsen), diabetic retinopathy that is not stabilized, severe renal impairment where dehydration from GI side effects raises risk, and any concurrent use of insulin or a sulfonylurea, where the additive glucose-lowering can produce hypoglycemia

With proper lifestyle changes, it is certainly possible not to gain weight once your Semaglutide treatment ends