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Furthermore, several novel therapeutic compounds (GIP receptor antagonists and agonists including multiple-targeting compounds) have also shown beneficial glucometabolic and body weight lowering effects in individuals with type 2 diabetes and obesity ( We recently assessed the role of endogenous GIP in individuals with obesity during fasting using GIP(3-30)NH 2

It has been demonstrated that cGAS-STING induces type I IFN production and further inhibits cytomegalovirus (CMV) replication in primary human endothelial cells (41)