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This study is interesting, but we will need larger, longitudinal, and ideally experimental studies to understand whether this association reflects a true pharmacological effect
The pathological changes in AD patients are typically characterized by senile plaques (SP) formed by the extracellular deposition of -amyloid (A) and neurofibrillary tangles (NFTs)
Strategies that work in the backcountry: Keep medication in the center of your pack, insulated from external heat Store the pack in shade whenever possible Use natural water sources, place the sealed vial in a waterproof bag and submerge it in a cool stream to bring the temperature down At camp, hang the medication bag in shade rather than leaving it in a tent (tents become ovens in sunlight) Consider timing your trip to avoid the hottest months, or bring enough doses for a shorter trip and resume at home If your trip falls during injection day, follow the injection site guidelines and maintain proper hygiene
Persistence remains mixed: a 2024 real-world study found 32% on therapy at 1 year among non-diabetic users, and according to Prime Therapeutics, only 1 in 12 remain at 3 years
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