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Alpha-lipoic acid may also contribute to acid reflux, as it is an acid

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It was found that DA can inhibit lipopolysaccharide (LPS)-induced activation of NLRP3 inflammasome and subsequent production of caspase-1 and IL-1 in a time- and dose-dependent manner through G protein pathway and -arrestindependent pathway ( Figure 1 )

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The interactions among immune cells, cytokine networks, and ammonium metabolism within the TME still requires further investigation

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