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Wnt/c-MYC and p65-NFkB pathways induce the expression of G6PD, activating PPP as part of a more metastatic and chemoresistant cancer phenotype (81, 82)

Omnivores' gastrointestinal tract has co-evolved in strict relationship with a dynamic microbiota and a complex seasonal and regional diet, resulting into a robust and flexible system tightly interconnected via multiple neuroendocrine axes with different organs