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The label expansion follows the FDAs March 2025 approval of an expanded label for lutetium Lu-177 vipivotide tetraxetan (Pluvicto) for use in patients with metastatic castration-resistant prostate cancer after treatment with an androgen receptor pathway inhibitor and before chemotherapy

The triple clt1 clt2 clt3 knockout has depleted cytosolic GSH and enriched chloroplastic GSH (Maughan et al., 2010)

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