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Notably, the activation of plaque macrophages by CD4 + T lymphocytes through CD40 ligand (CD40L)-CD40 signaling prompts the release of proinflammatory cytokines and exacerbates the recruitment of circulating monocytes

Seven weeks later, they had received no medication and no definitive update from Brello

The evidence indicates that intensive glucose control significantly prevents DPN in T1D but has limited effectiveness in T2D, reasons for this could be that T1D DPN is characterized by more severe structural degenerative changes, progressive axonal atrophy, and paranodal degenerative changes or maybe the difference could be caused owing to different susceptibility of nerve fibers to hyperglycemic damage between the two diabetes types