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Who Should Consider Oral Weight Loss Medications Healthcare providers typically prescribe oral weight loss medications for adults who meet specific criteria: BMI of 30 or higher (obesity) BMI of 27 or higher with weight-related health conditions like diabetes, high blood pressure, or sleep apnea Previous unsuccessful attempts at weight loss through diet and exercise alone Commitment to long-term lifestyle changes, including healthy eating and regular physical activity These medications work best when combined with comprehensive weight management strategies rather than used as standalone treatments