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Among participants with study-defined prediabetes, body weight reduction explained 52% (95% confidence interval [30.3, 87.8]) of the estimated treatment difference in HOMA2-IR observed at Week 72 (Table S2)

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Hiccups, medically termed singultus, are involuntary contractions of the diaphragm muscle followed by sudden closure of the vocal cords, producing the characteristic 'hic' sound