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When extracellular NAD+ levels in the bloodstream rise above normal, as can happen with high-dose IV infusions, the body may interpret this as trauma within the body, leading to an immune response, and potentially causing inflammation

Int J Clin Exp Pathol 8:1043610443 Yun ML et al (2008) Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells

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