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Common side effects The most common bupropion-naltrexone side effects are: Nausea: 32.5% compared to 6.7% taking placebo Constipation: 19.2% compared to 7.2% taking placebo Headache: 17.6% compared to 10.4% taking placebo Dizziness: 9.9% compared to 3.4% taking placebo Insomnia: 9.2% compared to 5.9% taking placebo Vomiting: 8.1% compared to 2.3% taking placebo These are likeliest to happen when you start taking the medication and typically fade as your body adjusts to it

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However, its generally recommended to administer the injection at a time that you can consistently stick to each week, as maintaining a routine is key to effectiveness