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Hence, by targeting the enzymatic activity of SARM1, inhibitors may effectively prevent the depletion of NAD + , thereby maintaining cellular energy homeostasis and enhancing neuronal resilience, potentially expanding the treatment landscape for various neurological conditions

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These instances of immune cell dysregulation are traced within the setting of MSU crystallization or sUA inflammatory models

C-Gpxs tend to have rate constants in the range 10 3-6 M/s, whereas Sec-Gpxs have rate constants in the range 10 6-7 M/s (Floh, 2012)