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Combination Therapies and Expanded Indications Combining medications often produces a synergistic effect, where the benefits are greater than the sum of the individual treatments

Biochim Biophys Acta 2001, 1546: 7986

After discontinuation, there was a pronounced rebound in weight (MD = 4.13 kg, 95% CI: 1.60 to 6.65), BMI (MD = 0.84 kg/m 2 , 95% CI: 0.37 to 1.32), WC (MD = 3.64 cm, 95% CI: 2.27 to 5.01), and HbA1c (SMD = 0.69, 95% CI: 0.50 to 0.89)