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GHK-Cu, commonly referred to as Copper Peptide, is a naturally occurring peptide complex that has been widely examined in laboratory research involving peptide signalling pathways, tissue remodelling models, and broader regenerative and cosmetic peptide systems

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Chelating this zinc signal with the membrane-permeable chelator TPEN effectively blocks the activation of LPS-induced signaling pathways, including the p38 MAPK, extracellular-signal regulated kinases 1/2 (ERK1/2) and NF-B pathways, ultimately inhibiting the release of proinflammatory cytokines such as TNF- [18]