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SodiumGlucose Cotransporter Inhibitors Function of SodiumGlucose Cotransporters in the Human Body Sodiumglucose cotransporter-2 (SGLT2) is a high-capacity, low-affinity transporter located solely in the luminal membrane of the S1 and S2 segments of the proximal convoluted tubule of nephrons, and they are responsible for about 90% of renal glucose reabsorption