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Its Phase 2 obesity trial published in Lancet Diabetes & Endocrinology (2024) showed up to 18.7% weight loss at 46 weeks, while a separate Phase 2 MASH trial demonstrated significant MASH resolution, earning FDA Breakthrough Therapy Designation

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Specific safety concerns warrant attention in certain populations

The FDA approved Eli Lilly's Foundayo (orforglipron) on April 1 the first oral GLP-1 pill for weight loss that can be taken at any time of day, with no fasting, food, or water restrictions