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Somanath, P.R., Ciocea, A

1e, f) suggested placement of polar and non-polar substituents in multiple locations, including those that were relatively remote, we intentionally limited the modifications to those in proximity or to the putative chimera molecule itself to maximize the potential for further improvements during structure-activity relationship (SAR) studies

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With a 30-minute half-life on the CJC-1295 (No DAC) side, spacing the two several hours apart means the GHRH signal has largely cleared before the ghrelin signal is working and the supra-additive effect is what you lose