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Optimal use involves standardized extracts, typically providing 200-400 mg of silymarin daily, often divided into multiple doses

This is known as bioavailability the degree and rate at which a substance is absorbed into the living system

Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance

In this context, Angeli et al