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The 2022 ASMBS/IFSO guidelines recommend consideration for patients with BMI 35 kg/m regardless of comorbidities, and for those with BMI 30-34.9 kg/m with metabolic disease

[57] Drugs that strongly inhibit CYP3A4, such as ketoconazole, itraconazole, or certain protease inhibitors, may reduce ondansetron clearance and potentially increase plasma concentrations

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In Vitro Dissolution Studies Dissolution is defined as the amount of drug substance that goes into the solution per unit time under standardized conditions of liquid/solid interface, temperature, and solvent concentration