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Mild side effects of Trulicity that have been reported include: abdominal pain burping constipation or diarrhea fatigue (low energy) indigestion injection-site reactions, which may cause rash, bruising, or pain loss of appetite nausea and vomiting weight loss Mild side effects of many drugs may go away within a few days to a couple of weeks

Cury J, Coelho RF, Srougi M

They help: Stimulate insulin production after meals (lowering blood sugar) Slow gastric emptying (so patients feel full longer) Reduce appetite through direct effects on the brain While originally approved for type 2 diabetes, some GLP1s, such as Saxenda, Wegovy and Zepbound, carry FDA approval for weight loss in adults with a BMI of 30 or more, or 27 with other health issues like high blood pressure or cholesterol

Advanced liver disease, renal failure