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To provide a more thorough theoretical foundation for treating disorders associated to TMAO, larger-scale clinical trials are needed to validate TMAOs potential as a biomarker for various diseases along the gut-organ axis

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The resulting GSH or homoglutathione (-L-glutamyl-L-cysteinyl--alanine) conjugates were usually much less toxic and more water-soluble than the original xenobiotics (Brown and Neighbors, 1998)

As there is an emphasis on preventive medicine in the healthcare industry and the treatment of metabolic diseases, demand for these oral medications will keep on increasing in the forecast period