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Volume overload correlates with cardiovascular risk factors in patients with chronic kidney disease

Although direct clinical evidence of systemic NAD(P) depletion during GLP-1RA therapy is lacking, experimental and observational studies suggest that NAD turnover and micronutrient status can be altered in obesity and inflammatory states [83, 85], supporting the biological plausibility of substrate-sensitive vulnerability

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On the contrary, orforglipron (RR 1.4640 [95% CI 0.2619, 8.1832